Born in Paris, Du Camp was the son of a successful surgeon. After finishing college, he indulged in his strong desire for travel, thanks to his father's assets. Du Camp traveled in Europe and the East between 1844 and 1845, and again between 1849 and 1851 in company with Gustave Flaubert. After his return, Du Camp wrote about his traveling experiences.
In 1851, Du Camp became a founder of the Revue de Paris (suppressed in 1858), and a frequent contributor to the Revue des deux mondes. In 1853, he became an officer of the Legion of Honour. Serving as a volunteer with Garibaldi in his 1860 conquest of the Kingdom of the Two Sicilies, Du Camp recounted his experiences in Expédition des deux Siciles (1861). In 1870 he was nominated for the senate, but his election was frustrated by the downfall of the Empire. He was elected a member of the French Academy in 1880, mainly, it is said, on account of his history of the Commune, published under the title of Les Convulsions de Paris (1878-1880).
Du Camp was an early amateur photographer whose travel books were among the first to be illustrated with photographs.
Maxime Du Camp died in 1894 and was buried in the Cimetière de Montmartre in the Montmartre Quarter of Paris.